Controlled protein release from monodisperse biodegradable double-wall microspheres of controllable shell thickness
Biodegradable polymer microparticles are promising delivery depots for protein therapeutics
due to their relatively simple fabrication and facile administration. Double-wall microspheres
(DWMS) comprising a core and shell made of two distinct polymers may provide enhanced
control of the drug release profiles. Using precision particle fabrication (PPF) technology,
monodisperse DWMS were fabricated with model protein bovine serum albumin (BSA)-
loaded poly (lactide-co-glycolide)(PLG) core and drug-free poly (d, l-lactic acid)(PDLL) shell …
due to their relatively simple fabrication and facile administration. Double-wall microspheres
(DWMS) comprising a core and shell made of two distinct polymers may provide enhanced
control of the drug release profiles. Using precision particle fabrication (PPF) technology,
monodisperse DWMS were fabricated with model protein bovine serum albumin (BSA)-
loaded poly (lactide-co-glycolide)(PLG) core and drug-free poly (d, l-lactic acid)(PDLL) shell …
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